Statin for Primary Prevention . Is it worth ?

The tasty of food and the rising of western food in The Malaysian comunity has make rising cholesterol an epidermic. The cholesterol has go up higher and higher in normal population on medical check up. Is statin is beneficial become an major thing to discuss.

Cochrane review showed that in the eight trials that reported on total mortality, none of the individual trials showed strong evidence of a reduction in total mortality, but when the data were pooled, a relative risk reduction of 17% was observed with statin treatment.No excess in combined adverse events, cancers, or specific biochemical markers were found. current systematic review highlights the shortcomings in the published trials of statins for primary prevention. They say that in people at high risk of cardiovascular events (>20% 10-year risk), "it is likely that the benefits of statins are greater than potential short-term harms, although long-term effects (over decades) remain unknown."
 recent meta-analysis from the Oxford group, published late last year, which showed a clear reduction in events with statin therapy in primary-prevention patients.

With the published of the cochrane and contraditing effects of Statin, therapy should be individulised. Patient with high risk of cardiovascular events (>20% in 10 years) worth for primary prevention. Whereas patient not fulfill the high risk Cv events, these need to be discussed with patient and decide .